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Gja5tm1Kwi
Targeted Allele Detail
Summary
Symbol: Gja5tm1Kwi
Name: gap junction protein, alpha 5; targeted mutation 1, Klaus Willecke
MGI ID: MGI:2445238
Synonyms: Cx40-
Gene: Gja5  Location: Chr3:96939718-96960950 bp, + strand  Genetic Position: Chr3, 42.04 cM
Alliance: Gja5tm1Kwi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46429
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A 5' region of exon 2, which is the only coding exon, was replaced with a neomycin selection cassette. No mRNA was detected by Northern blot analysis of heart or lung tissue obtained from homozygous mutant mice and the absence of protein was verified by Western blot analysis of liver tissue. (J:46429, J:83400)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gja5 Mutation:  19 strains or lines available
References
Original:  J:46429 Kirchhoff S, et al., Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice. Curr Biol. 1998 Feb 26;8(5):299-302
All:  33 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory