Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Juntm4Wag
Name:	jun proto-oncogene; targeted mutation 4, Erwin F Wagner
MGI ID:	MGI:2445420
Synonyms:	c-junf, junf, Junflox
Gene:	Jun  Location: Chr4:94937273-94940459 bp, - strand  Genetic Position: Chr4, 43.34 cM, cytoband C5-C7
Alliance:	Juntm4Wag page

Germline Transmission:	Earliest citation of germline transmission: J:75863
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The gene was flanked with a loxP site and a floxed neo-TK cassette via homologous recombination. The neo-TK cassette was removed in correctly targeted ES cells by transient expression of cre recombinase. The resulting mutation consists of Jun flanked by single loxP sites. (J:75863)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

List all tumor models in MMHCdb carrying Juntm4Wag

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jun Mutation:	12 strains or lines available

Original:	J:75863 Behrens A, et al., Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J. 2002 Apr 2;21(7):1782-90
All:	72 reference(s)