Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Pitx2tm4(cre)Jfm
Name:	paired-like homeodomain transcription factor 2; targeted mutation 4, James F Martin
MGI ID:	MGI:2445429
Synonyms:	delta abccreneo, Pitx2-Cre, Pitx2creneo, Pitx2 delta abccreneo
Gene:	Pitx2  Location: Chr3:128993527-129013240 bp, + strand  Genetic Position: Chr3, 57.84 cM
Alliance:	Pitx2tm4(cre)Jfm page

Germline Transmission:	Earliest citation of germline transmission: J:79853
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Pitx2tm4(cre)Jfm expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Pitx2 (MGI:109340)   Mutation details: Exon 5, which encodes a portion of the homeodomain, was disrupted by the insertion of a cassette containing IRES, cre recombinase, lacZ, and neo. In situ hybridization results showed that the expression pattern of cre was similar to that of the endogenous gene. The neo was removed by crossing to Flp-expressing mice. (J:79853, J:87220)

Activity:	Tissue activity of this recombinase allele
Driver:	Pitx2 (mouse) Summary of all recombinase alleles driven by Pitx2. Comparative matrix view of recombinase activities Alliance mouse Pitx2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:	39 strains or lines available

Original:	J:79853 Liu C, et al., Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development. 2002 Nov;129(21):5081-91
All:	32 reference(s)