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Gja5tm1Paul
Targeted Allele Detail
Summary
Symbol: Gja5tm1Paul
Name: gap junction protein, alpha 5; targeted mutation 1, David L Paul
MGI ID: MGI:2445466
Synonyms: Cx40-
Gene: Gja5  Location: Chr3:96939718-96960950 bp, + strand  Genetic Position: Chr3, 42.04 cM
Alliance: Gja5tm1Paul page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46430
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The single coding exon of the gene was deleted and replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by immunohistochemical analysis of frozen heart sections from homozygous mutant animals. (J:46430)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 36 assay results
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gja5 Mutation:  19 strains or lines available
References
Original:  J:46430 Simon AM, et al., Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr Biol. 1998 Feb 26;8(5):295-8
All:  29 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory