Gja1<tm1.1Kwi> Targeted Allele Detail MGI Mouse (MGI:2445472)

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Gja1^tm1.1Kwi
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Gja1^tm1.1Kwi
Name:	gap junction protein, alpha 1; targeted mutation 1., Klaus Willecke
MGI ID:	MGI:2445472
Synonyms:	Cx43^del
Gene:	Gja1 Location: Chr10:56253297-56266519 bp, + strand Genetic Position: Chr10, 28.64 cM
Alliance:	Gja1^tm1.1Kwi page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:78662
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1^b-m3

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The entire coding region contained within loxP sites flanking exon 2 and the floxed tk-neo cassette were removed by mating Gja1^tm1Kwi animals to cre deleter strain TgN(CMV-cre)1Cgn. Resulting progeny retained a single loxP site and lacZ cassette. (J:78662)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Gja1 Mutation:	60 strains or lines available

References

Original:	J:78662 Theis M, et al., Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene. Genesis. 2001 Jan;29(1):1-13
All:	16 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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