Tg(Sap-Mgat3)1Nta Transgene Detail MGI Mouse (MGI:2445494)

Tg(Sap-Mgat3)1Nta
Transgene Detail

Summary

Symbol:	Tg(Sap-Mgat3)1Nta
Name:	transgene insertion 1, Naoyuki Taniguchi
MGI ID:	MGI:2445494
Transgene:	Tg(Sap-Mgat3)1Nta Location: unknown
Alliance:	Tg(Sap-Mgat3)1Nta page

Transgene
origin

Strain of Origin:

Not Applicable

Transgene
description

Transgene Type:

Transgenic (Inserted expressed sequence)

Mutation:

Insertion

Tg(Sap-Mgat3)1Nta expresses 1 gene

Mutation details: A rat Mgat3 cDNA sequence fused to the Apcs promoter was used for the transgene. Transgene expression was confirmed by Northern blot analysis of livers RNA from transgenic animals. (J:80226)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Two transgenic founders were created, SAP-1 (4 copies of transgene) and SAP-2 (6 copies of transgene). Transgene expression and enzyme activity levels correlate to the number of copies present, with higher expression and activity in SAP-2 compared to SAP-1.

References

Original:	J:80226 Ihara Y, et al., Ectopic expression of N-acetylglucosaminyltransferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2526-30
All:	3 reference(s)

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