Tg(Camk2a-cre/ERT2)1Casa
Transgene Detail
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| Symbol: |
Tg(Camk2a-cre/ERT2)1Casa |
| Name: |
transgene insertion 1, Emilio Casanova |
| MGI ID: |
MGI:2445680 |
| Synonyms: |
ERiCreER, Tg(Camk2a-cre/Esr1)1Casa |
| Transgene: |
Tg(Camk2a-cre/ERT2)1Casa Location: unknown
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| Alliance: |
Tg(Camk2a-cre/ERT2)1Casa page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Camk2a-cre/ERT2)1Casa expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Camk2a |
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Mutation details: The transgene consists of a BAC vector carrying a tamoxifen-inducible cre recombinase gene under the control of Camk2a regulatory elements, an eGFP cassette, and a bovine growth hormone polyadenylation signal. The cre recombinase gene is flanked by 2 ERT2 ligand binding domains. The Camk2a promoter targets transgene expression to the brain. High expression was observed in the hippocampus and cortex, intermediate expression was observed in the striatum, thalamus, and hypothalamus, and no detectable expression was observed in the cerebellum. This transgenic line carries 8 copies of the integrated construct.
(J:80195)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Camk2a
(species not specified)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:80195 Casanova E, et al., ER-based double icre fusion protein allows partial recombination in forebrain. Genesis. 2002 Nov;34(3):208-14 |
| All: |
2 reference(s) |
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Analysis Tools
