Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol: Tg(Scgb1a1-rtTA)1Jaw Name: transgene insertion 1, Jeffrey A Whitsett MGI ID: MGI:2445707 Synonyms: CC10-rtTA, CCSP-rtTA, CCSPtg, Scgb1a1-rtTA, Tg(Ugb-rtTA)1Jaw Transgene: Tg(Scgb1a1-rtTA)1Jaw  Location: unknown   Alliance: Tg(Scgb1a1-rtTA)1Jaw page

Absence of proliferation during goblet cell hyperplasia in Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-Spdef)1Jaw/0 mice Show the 1 phenotype image(s) involving this allele.

Strain of Origin:

129 and C57BL/6

Transgene Type:    Transgenic (Transactivator) Mutation:    Insertion   Mutation details: The transgene is composed of 2.3 kb of rat Ugb (Scgb1a1) promoter, a reverse tetracycline responsive transactivator gene (rt-TA), and 2 kb of human growth hormone sequences, which includes introns and a polyadenylation signal. Transgene expression was confirmed by RT-PCR analysis. The rat Scgb1a1 promoter is active in respiratory epithelial cells. (J:61736)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Tg(Scgb1a1-rtTA)1Jaw

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available

Original:	J:61736 Tichelaar JW, et al., Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem. 2000 Apr 21;275(16):11858-64
All:	220 reference(s)