Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Tg(BGLAP-cre)1Clem
Name:	transgene insertion 1, Thomas L Clemens
MGI ID:	MGI:2446069
Synonyms:	HOC-cre, OC-cre, OC-cre line 6, OCNCre, osteocalcin-Cre
Transgene:	Tg(BGLAP-cre)1Clem  Location: unknown
Alliance:	Tg(BGLAP-cre)1Clem page

Strain of Origin:

FVB/NJ

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(BGLAP-cre)1Clem expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note human BGLAP (632) Bglap  (MGI:88156) Bglap2  (MGI:88157) Bglap3  (MGI:88155)   Mutation details: A human osteocalcin (BGLAP) promoter, driving expression in osteoblasts, fused to a cre recombinase gene was used for the transgene. The cre gene was modified to include a nuclear localization signal and human ACTB 3' untranslated region. Two lines were generated, 4 and 6. This allele represents line 6. Transgene expression was observed in the calvaria, femur, and vertebrae by Northern blot analysis. (J:80190)

Activity:	Tissue activity of this recombinase allele
Driver:	BGLAP (human) Summary of all recombinase alleles driven by BGLAP. Comparative matrix view of recombinase activities Alliance human BGLAP gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

104056 assay results 2 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:80190 Zhang M, et al., Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem. 2002 Nov 15;277(46):44005-12
All:	154 reference(s)