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Hmgcll1 Gene Detail
Summary
  • Symbol
    Hmgcll1
  • Name
    3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
  • Synonyms
    MGC:36512
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446108
    NCBI Gene: 208982
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:75922137-76043632 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 42.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3261 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446108
 protein coding gene Chr9:75921983-76043632 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035046
 protein coding gene Chr9:76359785-76489659 (+)
A/J MGP_AJ_G0035027
 protein coding gene Chr9:73689835-73813845 (+)
AKR/J MGP_AKRJ_G0034956
 protein coding gene Chr9:75462500-75587422 (+)
BALB/cJ MGP_BALBcJ_G0035019
 protein coding gene Chr9:73358265-73482722 (+)
C3H/HeJ MGP_C3HHeJ_G0034728
 protein coding gene Chr9:75918199-76043556 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035537
 protein coding gene Chr9:78383817-78525873 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032448
 protein coding gene Chr9:73017649-73139013 (+)
CAST/EiJ MGP_CASTEiJ_G0034050
 protein coding gene Chr9:76267101-76396515 (+)
CBA/J MGP_CBAJ_G0034700
 protein coding gene Chr9:81082137-81217603 (+)
DBA/2J MGP_DBA2J_G0034860
 protein coding gene Chr9:73355165-73478349 (+)
FVB/NJ MGP_FVBNJ_G0034802
 protein coding gene Chr9:72646151-72767478 (+)
LP/J MGP_LPJ_G0034941
 protein coding gene Chr9:76605027-76727234 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034843
 protein coding gene Chr9:82182036-82320226 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035560
 protein coding gene Chr9:75617081-75748046 (+)
PWK/PhJ MGP_PWKPhJ_G0033754
 protein coding gene Chr9:73626307-73750581 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033587
 protein coding gene Chr9:75842976-75980966 (+)
WSB/EiJ MGP_WSBEiJ_G0034162
 protein coding gene Chr9:75536993-75663654 (+)



Homology
more
  • Human Ortholog
    HMGCLL1, 3-hydroxy-3-methylglutaryl-CoA lyase like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGCLL1, 3-hydroxy-3-methylglutaryl-CoA lyase like 1
  • Synonyms
    bA418P12.1, er-cHL, ERCHL
  • Links
    NCBI Gene ID: 54511
    neXtProt AC: NX_Q8TB92
    UniProt: Q8TB92

  • Chr Location
    6p12.1; chr6:55434373-55678919 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    98
  • cDNA Data
    14
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007908 Ensembl Gene Model | MGI Sequence Detail 121496 C57BL/6J ±  kb
transcript ENSMUST00000008052 Ensembl | MGI Sequence Detail 3737 Not Applicable  
polypeptide ENSMUSP00000008052 Ensembl | MGI Sequence Detail 343 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 2
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
  • Latest
    J:294106 Soulez M, et al., Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models. Mol Cell Biol. 2019 Mar 15;39(6)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory