Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	En1tm2(cre)Wrst
Name:	engrailed 1; targeted mutation 2, Wolfgang Wurst
MGI ID:	MGI:2446434
Synonyms:	En1Cki, En1-Cre, En1Cre, En1tm6(cre)Alj
Gene:	En1  Location: Chr1:120530246-120535719 bp, + strand  Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
Alliance:	En1tm2(cre)Wrst page

Germline Transmission:	Earliest citation of germline transmission: J:62572
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Recombinase) Mutation:    Insertion   En1tm2(cre)Wrst expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse En1 (MGI:95389)   Mutation details: A cre recombinase gene cassette was inserted into the En1 locus. A loxP flanked neomycin cassette is removed in vivo via a Cre-mediated recombination event. (J:62572)

Activity:	Tissue activity of this recombinase allele
Driver:	En1 (mouse) Summary of all recombinase alleles driven by En1. Comparative matrix view of recombinase activities Alliance mouse En1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	404 assay results 11 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any En1 Mutation:	34 strains or lines available

Original:	J:62572 Kimmel RA, et al., Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation. Genes Dev. 2000 Jun 1;14(11):1377-89
All:	175 reference(s)