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Cmtm6 Gene Detail
Summary
  • Symbol
    Cmtm6
  • Name
    CKLF-like MARVEL transmembrane domain containing 6
  • Synonyms
    2810051A14Rik, Cklfsf6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447165
    NCBI Gene: 67213
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:114560184-114578412 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 65.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    584 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447165
 protein coding gene Chr9:114560184-114578412 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035393
 protein coding gene Chr9:117192572-117211131 (+)
A/J MGP_AJ_G0035373
 protein coding gene Chr9:112895564-112916063 (+)
AKR/J MGP_AKRJ_G0035306
 protein coding gene Chr9:115771462-115790383 (+)
BALB/cJ MGP_BALBcJ_G0035369
 protein coding gene Chr9:112704430-112722390 (+)
C3H/HeJ MGP_C3HHeJ_G0035077
 protein coding gene Chr9:116269449-116289280 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035892
 protein coding gene Chr9:120401334-120419393 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032775
 protein coding gene Chr9:110195137-110212756 (+)
CAST/EiJ MGP_CASTEiJ_G0034382
 protein coding gene Chr9:116139156-116156225 (+)
CBA/J MGP_CBAJ_G0035044
 protein coding gene Chr9:124913186-124938056 (+)
DBA/2J MGP_DBA2J_G0035203
 protein coding gene Chr9:112369463-112387392 (+)
FVB/NJ MGP_FVBNJ_G0035150
 protein coding gene Chr9:111194850-111212385 (+)
LP/J MGP_LPJ_G0035282
 protein coding gene Chr9:117525283-117549613 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035191
 protein coding gene Chr9:126136009-126153577 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035911
 protein coding gene Chr9:116144536-116164957 (+)
PWK/PhJ MGP_PWKPhJ_G0034088
 protein coding gene Chr9:112677078-112695940 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033922
 protein coding gene Chr9:116187821-116208819 (+)
WSB/EiJ MGP_WSBEiJ_G0034502
 protein coding gene Chr9:116024544-116047714 (+)



Homology
more
  • Human Ortholog
    CMTM6, CKLF like MARVEL transmembrane domain containing 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CMTM6, CKLF like MARVEL transmembrane domain containing 6
  • Synonyms
    CKLFSF6, PRO2219
  • Links
    NCBI Gene ID: 54918
    neXtProt AC: NX_Q9NX76
    UniProt: Q9NX76

  • Chr Location
    3p22.3; chr3:32481312-32502852 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Conditional knockout in Schwann cells leads to increased axon diameter in peripheral nerves which increases nerve conduction, affecting breathing, locomotion and sensory input.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    169
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67213 NCBI Gene Model | MGI Sequence Detail 18229 C57BL/6J ±  kb
transcript NM_026036 RefSeq | MGI Sequence Detail 3353 C57BL/6  
polypeptide Q9CZ69 UniProt | EBI | MGI Sequence Detail 183 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000029359 CKLF-like MARVEL transmembrane domain-containing protein 6
    (term hierarchy)
  • InterPro Domains
    IPR008253 Marvel domain
    IPR050578 MARVEL domain-containing and chemokine-like factor proteins
Molecular
Reagents
less
  • All nucleic 169
    cDNA 169

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914463, MGI:2142952
References
more
  • Summaries
    All 40
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory