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Hspa2tm1Dix
Targeted Allele Detail
Summary
Symbol: Hspa2tm1Dix
Name: heat shock protein 2; targeted mutation 1, David J Dix
MGI ID: MGI:2447605
Synonyms: Hsp70-2-
Gene: Hspa2  Location: Chr12:76450950-76453712 bp, + strand  Genetic Position: Chr12, 33.73 cM
Alliance: Hspa2tm1Dix page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:35110
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: The endogenous locus was disrupted by the insertion of a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of testicular tissue obtained from homozygous mutant mice. Immunostaining of testicular sections indicated an absence of normal protein in seminiferous tubules. (J:35110)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hspa2 Mutation:  24 strains or lines available
References
Original:  J:35110 Dix DJ, et al., Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3264-8
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory