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Mybl1tm1Epr
Targeted Allele Detail
Summary
Symbol: Mybl1tm1Epr
Name: myeloblastosis oncogene-like 1; targeted mutation 1, E Premkumar Reddy
MGI ID: MGI:2447613
Synonyms: A-myb-
Gene: Mybl1  Location: Chr1:9737640-9770434 bp, - strand  Genetic Position: Chr1, 2.08 cM
Alliance: Mybl1tm1Epr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39632
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: The DNA binding domain encoded by the endogenous locus was disrupted by the insertion of a neomycin selection cassette into exon 4. While Northern blot analysis of testicular tissue showed normal levels of transcript in heterozygous mice, no transcript was detected in homozygous mutant mice. Western blot analysis using a polyclonal antibody directed against the DNA binding domain confirmed the absence of normal protein in homozygous mutant mice. (J:39632)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mybl1 Mutation:  34 strains or lines available
References
Original:  J:39632 Toscani A, et al., Arrest of spermatogenesis and defective breast development in mice lacking A-myb. Nature. 1997 Apr 17;386(6626):713-7
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory