Hey2tm1Mtc
Targeted Allele Detail
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| Symbol: |
Hey2tm1Mtc |
| Name: |
hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 1, Michael T Chin |
| MGI ID: |
MGI:2447620 |
| Synonyms: |
CHF1- |
| Gene: |
Hey2 Location: Chr10:30708355-30718779 bp, - strand Genetic Position: Chr10, 17.19 cM, cytoband A4
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| Alliance: |
Hey2tm1Mtc page
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Hey2tm1Mtc/Hey2tm1Mtc mice have ventricular septal defects
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:80681
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Sequence encompassing 551 nt of the proximal promoter and exon 1 through the majority of exon 3 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 75 residues composing the amino terminal, basic region, and most of the helix-loop-helix domain. Transcript was undetected by RT-PCR analysis of cardiac ventricles obtained from homozygous mutant embryos.
(J:80681)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Hey2 Mutation: |
31 strains or lines available
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| Original: |
J:80681 Sakata Y, et al., Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16197-202 |
| All: |
8 reference(s) |
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Analysis Tools
