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Tg(Thy1-cre/PGR*)1Gsc
Transgene Detail
Summary
Symbol: Tg(Thy1-cre/PGR*)1Gsc
Name: transgene insertion 1, Gunther Schutz
MGI ID: MGI:2447655
Synonyms: Tg(Thy1-cre/PGR)1Gsc, TPR1
Transgene: Tg(Thy1-cre/PGR*)1Gsc  Location: unknown  
Alliance: Tg(Thy1-cre/PGR*)1Gsc page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    mifepristone
Mutation:    Insertion
 
Tg(Thy1-cre/PGR*)1Gsc expression driven by 1 gene
 
Mutation details: This transgene expresses a fusion protein consisting of Cre recombinase and a modified ligand-binding domain of the human progesterone receptor under the control of a mouse Thy1 promoter. The ligand-binding domain was modified such that it binds and can be activated by the synthetic steroid, RU486, but not the endogenous ligand, progesterone. Upon induction of transgene expression with RU486, activity was noted in the hippocampus and cortex. The activity was also noted in small populations of cells in the inferior colliculus, the striatum, the thalamus, the brain stem, and the cerebellum. (J:69323, J:84610)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Thy1 (mouse)
Summary of all recombinase alleles driven by Thy1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:69323 Kellendonk C, et al., Inducible site-specific recombination in the brain. J Mol Biol. 1999 Jan 8;285(1):175-82
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
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