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Mgrn1 Gene Detail
Summary
  • Symbol
    Mgrn1
  • Name
    mahogunin, ring finger 1
  • Synonyms
    2610042J20Rik, mKIAA0544, nc
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447670
    NCBI Gene: 17237
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:4704113-4756160 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.48 cM, cytoband A1
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1304 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447670
 protein coding gene Chr16:4703964-4756160 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022475
 protein coding gene Chr16:1400472-1458154 (+)
A/J MGP_AJ_G0022437
 protein coding gene Chr16:1214323-1268671 (+)
AKR/J MGP_AKRJ_G0022414
 protein coding gene Chr16:1406692-1462834 (+)
BALB/cJ MGP_BALBcJ_G0022442
 protein coding gene Chr16:1371900-1423403 (+)
C3H/HeJ MGP_C3HHeJ_G0022209
 protein coding gene Chr16:1428373-1484169 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022891
 protein coding gene Chr16:1484447-1545044 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020412
 protein coding gene Chr16:1140570-1193034 (+)
CAST/EiJ MGP_CASTEiJ_G0021735
 protein coding gene Chr16:1429875-1489247 (+)
CBA/J MGP_CBAJ_G0022178
 protein coding gene Chr16:1565034-1620734 (+)
DBA/2J MGP_DBA2J_G0022309
 protein coding gene Chr16:1321541-1373320 (+)
FVB/NJ MGP_FVBNJ_G0022284
 protein coding gene Chr16:1314939-1368220 (+)
LP/J MGP_LPJ_G0022377
 protein coding gene Chr16:1395701-1447777 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022306
 protein coding gene Chr16:1423350-1478817 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022903
 protein coding gene Chr16:1383970-1437582 (+)
PWK/PhJ MGP_PWKPhJ_G0021475
 protein coding gene Chr16:1388867-1446952 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021306
 protein coding gene Chr16:1472420-1524455 (+)
WSB/EiJ MGP_WSBEiJ_G0021784
 protein coding gene Chr16:1394121-1449368 (+)



Homology
more
  • Human Ortholog
    MGRN1, mahogunin ring finger 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MGRN1, mahogunin ring finger 1
  • Synonyms
    RNF156
  • Links
    NCBI Gene ID: 23295
    neXtProt AC: NX_O60291
    UniProt: O60291

  • Chr Location
    16p13.3; chr16:4616493-4690974 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 8 alleles in 11 genetic backgrounds
    1 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for mutant alleles exhibit darkening of agouti hair and suppression of the obesity associated with certain agouti mutations. Homozygotes for an induced null mutation also have curly whiskers and develop a progressive spongiform neuropathology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    59
  • cDNA Data
    11
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022517 Ensembl Gene Model | MGI Sequence Detail 52048 C57BL/6J ±  kb
    transcript ENSMUST00000023159 Ensembl | MGI Sequence Detail 3095 Not Applicable  
    polypeptide ENSMUSP00000023159 Ensembl | MGI Sequence Detail 556 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12160, MGD-MRK-12784, MGI:1923814, MGI:2146731, MGI:96946
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 36
    • Earliest
      J:166121 LYON MF, et al., A test for mutagenicity of caffeine in mice. Z Vererbungsl. 1962;93:7-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory