Gclmtm1Tdal
Targeted Allele Detail
|
|
| Symbol: |
Gclmtm1Tdal |
| Name: |
glutamate-cysteine ligase, modifier subunit; targeted mutation 1, Timothy P Dalton |
| MGI ID: |
MGI:2447852 |
| Synonyms: |
Gclm(-), GCLM- |
| Gene: |
Gclm Location: Chr3:122039206-122060864 bp, + strand Genetic Position: Chr3, 52.94 cM, cytoband H1-3
|
| Alliance: |
Gclmtm1Tdal page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:80927
|
| Parent Cell Line: |
Other (see notes) (ES Cell)
|
| Strain of Origin: |
129
|
|
| Allele Type: |
|
Targeted (Null/knockout) |
| Mutations: |
|
Insertion, Intragenic deletion
|
| |
|
Mutation details: Exon 1 was disrupted by the insertion of a neomycin selection cassette. The 3' splice donor site of intron 1 was deleted and translation from either of the putative start codons is expected to terminate after 61 residues. Neither normal transcript nor normal protein was detected by Northern and Western blot analyses of liver and kidney tissue obtained from homozygous mutant mice.
(J:80927)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Gclm Mutation: |
16 strains or lines available
|
|
|
ES cell line = J1 (129S4/SvJae) or D, which is E14TG2a (129P2/OlaHsd).
|
| Original: |
J:80927 Yang Y, et al., Initial Characterization of the Glutamate-Cysteine Ligase Modifier Subunit Gclm(-/-) Knockout Mouse. NOVEL MODEL SYSTEM FOR A SEVERELY COMPROMISED OXIDATIVE STRESS RESPONSE. J Biol Chem. 2002 Dec 20;277(51):49446-52 |
| All: |
27 reference(s) |
|
Analysis Tools
