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Trim63 Gene Detail
Summary
  • Symbol
    Trim63
  • Name
    tripartite motif-containing 63
  • Synonyms
    MuRF1, Rnf28
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447992
    NCBI Gene: 433766
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:134042431-134056940 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.58 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    546 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447992
 protein coding gene Chr4:134042431-134056940 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028923
 protein coding gene Chr4:136659840-136674218 (+)
A/J MGP_AJ_G0028882
 protein coding gene Chr4:130913162-130927670 (+)
AKR/J MGP_AKRJ_G0028834
 protein coding gene Chr4:134661997-134676599 (+)
BALB/cJ MGP_BALBcJ_G0028905
 protein coding gene Chr4:131552662-131572842 (+)
C3H/HeJ MGP_C3HHeJ_G0028619
 protein coding gene Chr4:134903639-134918734 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029347
 protein coding gene Chr4:141595399-141611656 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026618
 protein coding gene Chr4:123974212-123988345 (+)
CAST/EiJ MGP_CASTEiJ_G0028052
 protein coding gene Chr4:133027295-133041637 (+)
CBA/J MGP_CBAJ_G0028584
 protein coding gene Chr4:145314680-145332336 (+)
DBA/2J MGP_DBA2J_G0028733
 protein coding gene Chr4:131336890-131351982 (+)
FVB/NJ MGP_FVBNJ_G0028701
 protein coding gene Chr4:130229395-130243950 (+)
LP/J MGP_LPJ_G0028833
 protein coding gene Chr4:136753978-136769885 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028726
 protein coding gene Chr4:149809821-149825085 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029385
 protein coding gene Chr4:135100578-135117031 (+)
PWK/PhJ MGP_PWKPhJ_G0027772
 protein coding gene Chr4:128064092-128079509 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027598
 protein coding gene Chr4:130921114-130936036 (+)
WSB/EiJ MGP_WSBEiJ_G0028130
 protein coding gene Chr4:135265267-135281717 (+)



Homology
more
  • Human Ortholog
    TRIM63, tripartite motif containing 63
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM63, tripartite motif containing 63
  • Synonyms
    IRF, MURF1, MURF2, RNF28, SMRZ
  • Links
    NCBI Gene ID: 84676
    neXtProt AC: NX_Q969Q1
    UniProt: Q969Q1

  • Chr Location
    1p36.11; chr1:26051301-26068436 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 4 alleles in 4 genetic backgrounds
    25 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A targeted homozygous mutation in this gene results in resistance to skeletal muscle atrophy in response to nerve injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    4
  • cDNA Data
    10
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 433766 NCBI Gene Model | MGI Sequence Detail 14510 C57BL/6J ±  kb
    transcript NM_001039048 RefSeq | MGI Sequence Detail 1886 C57BL/6  
    polypeptide Q38HM4 UniProt | EBI | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 13
      Gene Ontology 12
      Phenotypes 37
    • Earliest
      J:77660 Bodine SC, et al., Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 2001 Nov 23;294(5547):1704-8
    • Latest
      J:326089 Ghnaimawi S, et al., The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis. Front Physiol. 2022;13:881624
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory