Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Nrg1tm2Zhou
Name:	neuregulin 1; targeted mutation 2, Mingdong Zhou
MGI ID:	MGI:2448078
Synonyms:	Nrg1tm
Gene:	Nrg1  Location: Chr8:32299493-33381858 bp, - strand  Genetic Position: Chr8, 18.75 cM
Alliance:	Nrg1tm2Zhou page

Germline Transmission:	Earliest citation of germline transmission: J:81106
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The majority of exon 11 and a portion of intron 11 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the transmembrane domain. (J:81106)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:	54 strains or lines available

Original:	J:81106 Stefansson H, et al., Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet. 2002 Oct;71(4):877-92
All:	35 reference(s)