Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Tg(tetO-cre)LC1Bjd
Name:	transgene insertion LC1, Hermann Bujard
MGI ID:	MGI:2448952
Synonyms:	LC-1, LC1-Cre, TgLC1, TRE-LC1
Transgene:	Tg(tetO-cre)LC1Bjd  Location: unknown  Genetic Position: Chr6, Syntenic
Alliance:	Tg(tetO-cre)LC1Bjd page

Strain of Origin:

(C57BL/6 x BALB/c)F2

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO-cre)LC1Bjd expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note bacteria tetO   Mutation details: The transgenic construct contained a bidirectional tTA/rtTA responsive promoter derived from the human cytomegalovirus promoter IE and flanked by sequence encoding luciferase and cre recombinase. Efficient cre mediated recombination, unaffected by position effect variegation, was demonstrated in hepatocytes. Transcription of in both directions was shown to be activated by rtTA in the presence of doxycycline. Transgene insertion is on chromosome 6C1 flanked by genes coding for the vomeronasal receptors V1rc14 and V1rc15 (K.Schonig, pers. commun.) (J:81196)

Activity:	Tissue activity of this recombinase allele
Driver:	tetO (bacteria) Summary of all recombinase alleles driven by tetO.

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

27 assay results

List all tumor models in MMHCdb carrying Tg(tetO-cre)LC1Bjd

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:81196 Schonig K, et al., Stringent doxycycline dependent control of CRE recombinase in vivo. Nucleic Acids Res. 2002 Dec 1;30(23):e134
All:	137 reference(s)