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Nkx2-5tm2(cre)Rph
Targeted Allele Detail
Summary
Symbol: Nkx2-5tm2(cre)Rph
Name: NK2 homeobox 5; targeted mutation 2, Richard P Harvey
MGI ID: MGI:2448972
Synonyms: Nkx2.5-Cre, Nkx2-5IRESCre
Gene: Nkx2-5  Location: Chr17:27057638-27063962 bp, - strand  Genetic Position: Chr17, 13.6 cM
Alliance: Nkx2-5tm2(cre)Rph page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80725
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (No functional change, Recombinase)
Mutation:    Insertion
 
Nkx2-5tm2(cre)Rph expression driven by 1 gene
 
Mutation details: Sequence encoding cre recombinase adjoined to an IRES was inserted into the 3' UTR of the endogenous locus via homologous recombination. A single frt site remained in the UTR after an frt-flanked hygromycin selection cassette was excised. A lack of observed allele complementation indicated that the inserted sequence did not significantly affect expression of the endogenous locus. (J:80725)
Generation of the Smyd2tm1.1Fben allele
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nkx2-5 (mouse)
Summary of all recombinase alleles driven by Nkx2-5.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 203 assay results
12 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkx2-5 Mutation:  21 strains or lines available
References
Original:  J:80725 Stanley EG, et al., Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int J Dev Biol. 2002;46(4):431-9
All:  78 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory