About   Help   FAQ
Tg(ACTFLPe)9205Dym
Transgene Detail
Summary
Symbol: Tg(ACTFLPe)9205Dym
Name: transgene insertion 9205, Susan Dymecki
MGI ID: MGI:2448985
Synonyms: ACTB-Flpe, ACTB::FLPe, ACTB:FLPe, ACTFlpe, ACT-FLPe, actin-FLPe, beta-actinFLPe, CAGG-Flpr, CAGGS-flp, Flp, Flp deleter, FLPe, hACTB-FLPe, hACTB::FLPe, Tg(ACTB-flpe)9205Dym, Tg(ACTB-FlpE)9205Dym, Tg (ACTFLEe)9205Dym, TgaFlpe, TgpCAG-flpe
Transgene: Tg(ACTFLPe)9205Dym  Location: unknown  
Alliance: Tg(ACTFLPe)9205Dym page
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(ACTFLPe)9205Dym expression driven by 1 gene
 
Mutation details: Sequence encoding FLP1 was adjoined to human ACTB promoter sequence, including 3 kb of promoter sequence and an 0.8 kb portion of exon 1. The promoter region drives expression in the germline. Recombinase activity is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5. (J:78660)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: ACTB (human)
Summary of all recombinase alleles driven by ACTB.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Notes
The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37C and 40C, respectively. Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
References
Original:  J:78660 Rodriguez CI, et al., High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet. 2000 Jun;25(2):139-40
All:  1160 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory