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A2m Gene Detail
Summary
  • Symbol
    A2m
  • Name
    alpha-2-macroglobulin
  • Synonyms
    A2mp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449119
    NCBI Gene: 232345
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:121612920-121656197 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.49 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1254 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449119
 protein coding gene Chr6:121612335-121656197 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031219
 protein coding gene Chr6:124595355-124636498 (+)
A/J MGP_AJ_G0031188
 protein coding gene Chr6:119796913-119836547 (+)
AKR/J MGP_AKRJ_G0031119
 protein coding gene Chr6:123027278-123066904 (+)
BALB/cJ MGP_BALBcJ_G0031199
 protein coding gene Chr6:119565552-119607493 (+)
C3H/HeJ MGP_C3HHeJ_G0030917
 protein coding gene Chr6:123048497-123089307 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031657
 protein coding gene Chr6:127775561-127822575 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028817
 protein coding gene Chr6:116710814-116713350 (+)
CAST/EiJ MGP_CASTEiJ_G0030306
 protein coding gene Chr6:123512191-123551538 (+)
CBA/J MGP_CBAJ_G0030882
 protein coding gene Chr6:132856140-132899046 (+)
DBA/2J MGP_DBA2J_G0031038
 protein coding gene Chr6:118678411-118720803 (+)
FVB/NJ MGP_FVBNJ_G0030990
 protein coding gene Chr6:117820950-117861296 (+)
LP/J MGP_LPJ_G0031117
 protein coding gene Chr6:124574628-124617169 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031024
 protein coding gene Chr6:136791057-136840453 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031686
 protein coding gene Chr6:123062655-123102310 (+)
PWK/PhJ MGP_PWKPhJ_G0030021
 protein coding gene Chr6:117727604-117769536 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029850
 protein coding gene Chr6:121799928-121840754 (+)
WSB/EiJ MGP_WSBEiJ_G0030389
 protein coding gene Chr6:123359706-123400819 (+)



Homology
more
  • Human Ortholog
    A2M, alpha-2-macroglobulin
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    A2M, alpha-2-macroglobulin
  • Synonyms
    A2MD, CPAMD5, FWP007, S863-7
  • Links
    NCBI Gene ID: 2
    neXtProt AC: NX_P01023
    UniProt: P01023

  • Chr Location
    12p13.31; chr12:9067664-9116229 (-)  GRCh38
Human Diseases
more
  • Diseases
    6 with human A2M associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    998
  • Tissues
    69
  • cDNA Data
    57
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 232345 NCBI Gene Model | MGI Sequence Detail 43278 C57BL/6J ±  kb
transcript NM_175628 RefSeq | MGI Sequence Detail 4687 ZRU/MplStud  
polypeptide Q6GQT1 UniProt | EBI | MGI Sequence Detail 1474 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000024845 alpha-2-macroglobulin
    (term hierarchy)
  • InterPro Domains
    IPR001599 Alpha-2-macroglobulin
    IPR011625 Alpha-2-macroglobulin, bait region domain
    IPR050473 Alpha-2-macroglobulin/Complement system
    IPR019742 Alpha-2-macroglobulin, conserved site
    IPR041813 Alpha-2-macroglobulin, TED domain
    IPR011626 Alpha-macroglobulin-like, TED domain
    IPR047565 Alpha-macroglobulin-like, thiol-ester bond-forming region
    IPR009048 Alpha-macroglobulin, receptor-binding
    IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily
    IPR014756 Immunoglobulin E-set
    IPR013783 Immunoglobulin-like fold
    IPR002890 Macroglobulin domain
    IPR041555 Macroglobulin domain MG3
    IPR040839 Macroglobulin domain MG4
    IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
  • GlyGen
    Q6GQT1 12 sites, 1 N-linked glycan (3 sites), 1 O-linked glycan (3 sites)
Molecular
Reagents
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  • All nucleic 60
    cDNA 57
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 67
    Developmental Gene Expression 12
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:30080 Hudson NW, et al., Subunit and primary structure of a mouse alpha-macroglobulin, a human alpha 2-macroglobulin homologue. Biochim Biophys Acta. 1982 Jun 4;704(2):290-303
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory