Psen1<tm2.1Shn> Targeted Allele Detail MGI Mouse (MGI:2449306)

Psen1^tm2.1Shn
Targeted Allele Detail

Summary

Symbol:	Psen1^tm2.1Shn
Name:	presenilin 1; targeted mutation 2.1, Jie Shen
MGI ID:	MGI:2449306
Synonyms:	PS1^delta
Gene:	Psen1 Location: Chr12:83734926-83781869 bp, + strand Genetic Position: Chr12, 38.84 cM
Alliance:	Psen1^tm2.1Shn page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:71606
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A single loxP site was inserted into intron 1 and a loxP-flanked hygromycin and thymidine kinase selection cassette was inserted into intron 3. Exons 2 and 3 and the drug selection cassette were removed in ES cells by transient Cre expression in ES cells prior to the production of mice. The final allele has a single loxP site in place of exons 2 and 3. (J:71606)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

30 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Psen1 Mutation:	48 strains or lines available

References

Original:	J:71606 Yu H, et al., App processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron. 2001 Sep 13;31(5):713-26
All:	3 reference(s)

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