Gdf11<tm1Sjl> Targeted Allele Detail MGI Mouse (MGI:2449672)

Gdf11^tm1Sjl
Targeted Allele Detail

Summary

Symbol:	Gdf11^tm1Sjl
Name:	growth differentiation factor 11; targeted mutation 1, Sejin Lee
MGI ID:	MGI:2449672
Synonyms:	Gdf11-
Gene:	Gdf11 Location: Chr10:128718164-128727587 bp, - strand Genetic Position: Chr10, 77.18 cM, cytoband D3
Alliance:	Gdf11^tm1Sjl page

Axial skeleton patterning defects in Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl, Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Fst^tm1Zuk/Fst^tm1Zuk, Gdf11^tm1Sjl/Gdf11⁺ and Gdf11^tm1Sjl/Gdf11^tm1Sjl mice.

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:55879
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Sequence encoding the majority of the carboxy terminal, which putatively contains the biologically active portion of the protein, was replaced with a neo cassette inserted by homologous recomibation. (J:55879)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	131 assay results
In Structures Affected by this Mutation:	27 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Gdf11 Mutation:	13 strains or lines available

References

Original:	J:55879 McPherron AC, et al., Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11. Nat Genet. 1999 Jul;22(3):260-4
All:	19 reference(s)

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