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Gdf11tm1Clf
Targeted Allele Detail
Summary
Symbol: Gdf11tm1Clf
Name: growth differentiation factor 11; targeted mutation 1, Anne L Calof
MGI ID: MGI:2449673
Synonyms: Gdf11tm2
Gene: Gdf11  Location: Chr10:128718164-128727587 bp, - strand  Genetic Position: Chr10, 77.18 cM, cytoband D3
Alliance: Gdf11tm1Clf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81451
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: Exon 3 was disrupted by the insertion of a PGK-neo cassette. The targeted allele putatively encodes a transcript lacking four of seven essential cysteine codons. RT-PCR analysis of total RNA obtained from olfactory turbinates indicated an absence of normal transcript in homozygous mutant embryos. (J:81451)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gdf11 Mutation:  13 strains or lines available
References
Original:  J:81451 Wu HH, et al., Autoregulation of Neurogenesis by GDF11. Neuron. 2003 Jan 23;37(2):197-207
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory