Lrp2<tm1Tew> Targeted Allele Detail MGI Mouse (MGI:2449765)

Lrp2^tm1Tew
Targeted Allele Detail

Summary

Symbol:	Lrp2^tm1Tew
Name:	low density lipoprotein receptor-related protein 2; targeted mutation 1, Thomas E Willnow
MGI ID:	MGI:2449765
Synonyms:	megalin^lox
Gene:	Lrp2 Location: Chr2:69254679-69416373 bp, - strand Genetic Position: Chr2, 40.74 cM
Alliance:	Lrp2^tm1Tew page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:81496
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: 3 exons were flanked by a 5' floxed neo cassette and a 3' single loxP site. The most 3' exon in the floxed region encodes the membrane anchor of the receptor. Western blot analysis of kidney tissue obtained from homozygous mutant mice indicated that a protein product was produced by the floxed allele. (J:81496)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Lrp2 Mutation:	261 strains or lines available

References

Original:	J:81496 Leheste JR, et al., Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J. 2003 Feb;17(2):247-9
All:	34 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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