Rettm1Jmi
Targeted Allele Detail
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| Symbol: |
Rettm1Jmi |
| Name: |
ret proto-oncogene; targeted mutation 1, Jeffrey Milbrandt |
| MGI ID: |
MGI:2449909 |
| Synonyms: |
RetGFP, RetTGM |
| Gene: |
Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
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| Alliance: |
Rettm1Jmi page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:71881
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| Parent Cell Line: |
RW-4 (ES Cell)
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| Strain of Origin: |
129X1/SvJ
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutation: |
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Insertion
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Mutation details: The gene was disrupted by insertion of an EGFP-derived cassette and a floxed neo cassette into exon 1 via homologous recombination. The floxed neo cassette was removed by mating mutant animals to cre deleter strain TgN(ACTB-cre)2Mrt. Immunohistochemical analysis of homozygous mutant newborns confirmed the absence of gene expression in spinal motorneurons.
(J:71881)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ret Mutation: |
54 strains or lines available
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Homozygous mutant animals lacked kidneys and enteric neurons and died shortly after birth.
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| Original: |
J:71881 Enomoto H, et al., RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons. Development. 2001 Oct;128(20):3963-74 |
| All: |
36 reference(s) |
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Analysis Tools
