Fev<tm1Esd> Targeted Allele Detail MGI Mouse (MGI:2449922)

Fev^tm1Esd
Targeted Allele Detail

Summary

Symbol:	Fev^tm1Esd
Name:	FEV transcription factor, ETS family member; targeted mutation 1, Evan S Deneris
MGI ID:	MGI:2449922
Synonyms:	Pet-1^-, Pet1^-, Pet-1 KO
Gene:	Fev Location: Chr1:74920668-74924578 bp, - strand
Alliance:	Fev^tm1Esd page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:81450
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The entire coding region was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by in situ hybridization of hindbrain tissue obtained from homozygous mutant mice. (J:81450)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

18 assay results
1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Fev Mutation:	14 strains or lines available

References

Original:	J:81450 Hendricks TJ, et al., Pet-1 ETS Gene Plays a Critical Role in 5-HT Neuron Development and Is Required for Normal Anxiety-like and Aggressive Behavior. Neuron. 2003 Jan 23;37(2):233-47
All:	32 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24