Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Commd10Tg(Vav1-icre)A2Kio
Name:	COMM domain containing 10; transgene insertion A2, Dimitris Kioussis
MGI ID:	MGI:2449949
Synonyms:	Tg(Vav1-cre)1Kio, Tg(Vav1-cre)A2Kio, Tg(Vav1-icre)A2Kio, Vav1-Cre, Vav1 (HS21/5)-iCre, Vav-cre, VavCre, VavCredeBoer, Vav-iCre
Gene:	Commd10  Location: Chr18:47091917-47242435 bp, + strand  Genetic Position: Chr18, 24.9 cM
Alliance:	Commd10Tg(Vav1-icre)A2Kio page

Strain of Origin:

(CBA/Ca x C57BL/10)F2

Transgene Type:    Transgenic (Null/knockout, Recombinase) Mutation:    Insertion   Commd10Tg(Vav1-icre)A2Kio expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Vav1   Mutation details: This transgene expresses Cre recombinase under the control of a vav promoter. This promoter was shown to be active in lymph nodes, thymus, spleen, Peyer's patches, intestinal cryptopatches, ovaries and testes. Line A2 inserted into the gene at 47022629-47022630 (Build GRCm38/mm10). The insetion results in a functional knock-out in homozygous mice. (J:81568)

Activity:	Tissue activity of this recombinase allele
Driver:	Vav1 (species not specified) Summary of all recombinase alleles driven by Vav1. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

28 assay results 19 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Commd10Tg(Vav1-icre)A2Kio

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Commd10 Mutation:	24 strains or lines available

Original:	J:81568 De Boer J, et al., Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur J Immunol. 2003 Feb;33(2):314-25
All:	579 reference(s)