Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Tek-cre)1Ywa
Name:	transgene insertion 1, Masashi Yanagisawa
MGI ID:	MGI:2450311
Synonyms:	T2Cre, TekCre, Tie-2 Cre, Tie2-Cre, Tie2Cre, Tie2Cre+
Transgene:	Tg(Tek-cre)1Ywa  Location: unknown  Genetic Position: Chr5, Syntenic
Alliance:	Tg(Tek-cre)1Ywa page

Strain of Origin:

(C57BL/6 x SJL)F1

Transgene Type:    Transgenic (Hypomorph, Recombinase) Mutations:    Insertion, Intragenic deletion   Tg(Tek-cre)1Ywa involves 1 genes/genome features (Sorcs2) View all   Tg(Tek-cre)1Ywa expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Tek (MGI:98664)   Mutation details: This transgene expresses Cre recombinase under the control of a mouse Tek promoter and enhancer. This promoter is active in endothelial cells. Insertion within intron 1 of Sorcs2 results in the 204 bp deletion (36382105 to 36382309 on mouse chromosome 5; GRCm37/mm9 genome build) leading to reduced and variable expression. (J:67365, J:71269, J:242313)

Activity:	Tissue activity of this recombinase allele
Driver:	Tek (mouse) Summary of all recombinase alleles driven by Tek. Comparative matrix view of recombinase activities Alliance mouse Tek gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	282 assay results 15 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

List all tumor models in MMHCdb carrying Tg(Tek-cre)1Ywa

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available

Original:	J:67365 Kisanuki YY, et al., Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol. 2001 Feb 15;230(2):230-42
All:	776 reference(s)