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Tg(CD2-cre)1Tjw
Transgene Detail
Summary
Symbol: Tg(CD2-cre)1Tjw
Name: transgene insertion 1, Trevor J Wilson
MGI ID: MGI:2450356
Synonyms: CD2Cre, CD2-Cre
Transgene: Tg(CD2-cre)1Tjw  Location: unknown  
Alliance: Tg(CD2-cre)1Tjw page
Transgene
origin
Strain of Origin:  (CBA x C57BL/6)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(CD2-cre)1Tjw expression driven by 1 gene
 
Mutation details: The transgene consists of a modified cre recombinase gene fused to exon 1 of a human CD2 minigene just upstream of the translation initiation codon. The human CD2 promoter was used to drive transgene expression in T lymphocytes. The cre recombinase sequence was modified to include a nuclear localization signal and a modified KOZAK consensus sequence. Transgene expression was confirmed by immunohistochemical analysis of thymus and spleen from transgenic animals. (J:81648)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: CD2 (human)
Summary of all recombinase alleles driven by CD2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Two transgenic founders displaying similar cre expression patterns were created.
References
Original:  J:81648 Wilson TJ, et al., A human CD2 minigene directs CRE-mediated recombination in T cells in vivo. Genesis. 2002 Aug;33(4):181-4
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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07/02/2024
MGI 6.13 		The Jackson Laboratory