Ros1tm1Cbm
Targeted Allele Detail
|
|
| Symbol: |
Ros1tm1Cbm |
| Name: |
Ros1 proto-oncogene; targeted mutation 1, Carmen Birchmeier |
| MGI ID: |
MGI:2450566 |
| Synonyms: |
c-ros-, rosex |
| Gene: |
Ros1 Location: Chr10:51921817-52071340 bp, - strand Genetic Position: Chr10, 26.18 cM
|
| Alliance: |
Ros1tm1Cbm page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:33259
|
| Parent Cell Line: |
E14.1 (ES Cell)
|
| Strain of Origin: |
129P2/OlaHsd
|
|
| Allele Type: |
|
Targeted (Null/knockout) |
| Mutation: |
|
Insertion
|
| |
|
Mutation details: A neomycin resistance cassette containing stop codons in all three reading frames was inserted into an exon that encodes the extracellular domain. This region corresponds to nucleotides 2962-3370 of the cDNA. Northern blot analyses of intestine from homozygous mutant mice detected two neo fusion transcripts using a cDNA probe for extracellular sequences and did not detect wild-type transcript. A cDNA probe for kinase sequences detected only one of the fusion transcripts. Northern blot analysis of testis dissected from homozygous mutant embryos detected wild-type transcript using a cDNA probe for kinase sequences. Western blot analysis using antibodies against a carboxy-terminal peptide did not detect protein in epididymal extracts from homozygous mutant mice.
(J:33259)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Ros1 Mutation: |
145 strains or lines available
|
|
| Original: |
J:33259 Sonnenberg-Riethmacher E, et al., The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis. Genes Dev. 1996 May 15;10(10):1184-93 |
| All: |
10 reference(s) |
|
Analysis Tools
