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Gmcl1tm1Nkn
Targeted Allele Detail
Summary
Symbol: Gmcl1tm1Nkn
Name: germ cell-less, spermatogenesis associated 1; targeted mutation 1, Toru Nakano
MGI ID: MGI:2450853
Synonyms: mgcl-1-
Gene: Gmcl1  Location: Chr6:86668750-86710365 bp, - strand  Genetic Position: Chr6, 37.75 cM
Alliance: Gmcl1tm1Nkn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81819
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 2 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of testes protein extracts. (J:81819)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gmcl1 Mutation:  40 strains or lines available
References
Original:  J:81819 Kimura T, et al., Mouse germ cell-less as an essential component for nuclear integrity. Mol Cell Biol. 2003 Feb;23(4):1304-15
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory