B4galt1<tm1Yiw> Targeted Allele Detail MGI Mouse (MGI:2450889)

B4galt1^tm1Yiw
Targeted Allele Detail

Summary

Symbol:	B4galt1^tm1Yiw
Name:	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1; targeted mutation 1, Yoichiro Iwakura
MGI ID:	MGI:2450889
Synonyms:	Beta4GalT-I^-, GalT^-
Gene:	B4galt1 Location: Chr4:40804602-40854005 bp, - strand Genetic Position: Chr4, 20.46 cM
Alliance:	B4galt1^tm1Yiw page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:40026
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exon 1 was replaced with a PGK-neo cassette inserted by homologous recombination. The deleted exon contained the start codon and encoded the golgi retention signal. While the targeting vector was designed to disrupt both long and short isoforms, assays showed residual endogenous activity (less than 5% of wild-type levels) in homozygous mutant mice. (J:40026)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any B4galt1 Mutation:	43 strains or lines available

References

Original:	J:40026 Asano M, et al., Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells. EMBO J. 1997 Apr 15;16(8):1850-7
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24