Wnt3<tm1Amc> Targeted Allele Detail MGI Mouse (MGI:2450902)

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Wnt3^tm1Amc
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Wnt3^tm1Amc
Name:	wingless-type MMTV integration site family, member 3; targeted mutation 1, Andrew P McMahon
MGI ID:	MGI:2450902
Synonyms:	Wnt3^n/n
Gene:	Wnt3 Location: Chr11:103664976-103708783 bp, + strand Genetic Position: Chr11, 67.5 cM
Alliance:	Wnt3^tm1Amc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:81795
Parent Cell Line:	CC1.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		The gene was disrupted by insertion of an MC1neo cassette into exon 4 via homologous recombination. (J:81795)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Wnt3 Mutation:	25 strains or lines available

References

Original:	J:81795 Barrow JR, et al., Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev. 2003 Feb 1;17(3):394-409
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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