About   Help   FAQ
Mettm4.1Cpo
Targeted Allele Detail
Summary
Symbol: Mettm4.1Cpo
Name: met proto-oncogene; targeted mutation 4.1, Carola Ponzetta
MGI ID: MGI:2450967
Synonyms: Metgrb2neo-
Gene: Met  Location: Chr6:17463799-17573979 bp, + strand  Genetic Position: Chr6, 7.83 cM, cytoband A2
Alliance: Mettm4.1Cpo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81793
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation details: This allele is derived from Mettm4Cpo by crossing mutant animals to cre deleter strain TgN(CMV-cre)1Cgn. This results in deletion of the floxed neo cassette leaving behind the mutant human cDNA sequence carrying a Y1358N knock-in mutation. (J:81793)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Met Mutation:  83 strains or lines available
References
Original:  J:81793 Ieraci A, et al., Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15200-5
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory