Fmr1<tm2Cgr> Targeted Allele Detail MGI Mouse (MGI:2451086)

Fmr1^tm2Cgr
Targeted Allele Detail

Summary

Symbol:	Fmr1^tm2Cgr
Name:	fragile X messenger ribonucleoprotein 1; targeted mutation 2, Ben Oostra
MGI ID:	MGI:2451086
Synonyms:	CGG(98)
Gene:	Fmr1 Location: ChrX:67722147-67761569 bp, + strand Genetic Position: ChrX, 34.83 cM
Alliance:	Fmr1^tm2Cgr page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:71202
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Humanized sequence)
Mutation:		Nucleotide repeat expansion
		Mutation details: The mouse promoter 8 CGG repeat sequence was replaced with a human 98 CGG repeat and a floxed neo cassette via homologous recombination. The targeted allele was verified by PCR analysis. Germline passage of this allele results in contraction and expansion of the CGG repeats. (J:71202)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Fmr1 Mutation:	29 strains or lines available

References

Original:	J:71202 Bontekoe CJ, et al., Instability of a (CGG)98 repeat in the Fmr1 promoter. Hum Mol Genet. 2001 Aug 1;10(16):1693-9
All:	32 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24