Atp1a1<tm1Ling> Targeted Allele Detail MGI Mouse (MGI:2451290)

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Atp1a1^tm1Ling
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Atp1a1^tm1Ling
Name:	ATPase, Na+/K+ transporting, alpha 1 polypeptide; targeted mutation 1, Jerry B Lingrel
MGI ID:	MGI:2451290
Synonyms:	alpha1^-
Gene:	Atp1a1 Location: Chr3:101483535-101512000 bp, - strand Genetic Position: Chr3, 44.3 cM, cytoband F3
Alliance:	Atp1a1^tm1Ling page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:55191
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exons 15 through 18 were replaced with an hprt cassette via homologous recombination. Both alpha 1 transcript and protein levels were reduced by ~40% in heterozygous mutant hearts. An aberrant alpha 1 transcript was detected but was not expected to produce a functional protein. (J:55191)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	5 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Atp1a1 Mutation:	61 strains or lines available

References

Original:	J:55191 James PF, et al., Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart. Mol Cell. 1999 May;3(5):555-63
All:	16 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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