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Atp1a2tm2Ling
Targeted Allele Detail
Summary
Symbol: Atp1a2tm2Ling
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide; targeted mutation 2, Jerry B Lingrel
MGI ID: MGI:2451291
Synonyms: alpha2-
Gene: Atp1a2  Location: Chr1:172099276-172125631 bp, - strand  Genetic Position: Chr1, 79.6 cM
Alliance: Atp1a2tm2Ling page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55191
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: The insertion of an hprt cassette into exon 4 resulted in an alpha 2 isoform specific disruption. Both alpha 2 transcript and protein levels were reduced by ~50% in heterozygous mutant hearts. An aberrant alpha 2 transcript was detected but was not expected to produce a functional protein. (J:55191)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 39 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp1a2 Mutation:  62 strains or lines available
References
Original:  J:55191 James PF, et al., Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart. Mol Cell. 1999 May;3(5):555-63
All:  13 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory