Aldh1a2<tm1Dll> Targeted Allele Detail MGI Mouse (MGI:2451316)

Aldh1a2^tm1Dll
Targeted Allele Detail

Summary

Symbol:	Aldh1a2^tm1Dll
Name:	aldehyde dehydrogenase family 1, subfamily A2; targeted mutation 1, Pascal Dolle
MGI ID:	MGI:2451316
Synonyms:	Raldh2^neo
Gene:	Aldh1a2 Location: Chr9:71123071-71203525 bp, + strand Genetic Position: Chr9, 39.85 cM
Alliance:	Aldh1a2^tm1Dll page

Outflow tract septation defects and abnormal patterns of aortic arch-derived arteries in Aldh1a2^tm1Dll/Aldh1a2^tm1Dll and Aldh1a2^tm1Dll/Aldh1a2^tm1Ipc mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:81969
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Conditional ready, Hypomorph)
Mutation:		Insertion
		Mutation details: Exon 4 was flanked by a single loxP site in intron 3 and a floxed neo cassette in intron 4. This allele was shown to be hypomorphic by in situ hybridization and immunohistochemical analysis, which showed reduced levels of transcript and protein in homozygous mutant embyros. (J:81969)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	26 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Aldh1a2 Mutation:	38 strains or lines available

References

Original:	J:81969 Vermot J, et al., Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1763-8
All:	19 reference(s)

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