Scn2btm1Isom
Targeted Allele Detail
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| Symbol: |
Scn2btm1Isom |
| Name: |
sodium channel, voltage-gated, type II, beta; targeted mutation 1, Lori L Isom |
| MGI ID: |
MGI:2451362 |
| Synonyms: |
Beta2-, Scn2btm1Lli |
| Gene: |
Scn2b Location: Chr9:45029174-45041368 bp, + strand Genetic Position: Chr9, 24.84 cM
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| Alliance: |
Scn2btm1Isom page
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 2 and 3, which encode the mature protein, were replaced with a neo cassette inserted by homologous recombination. Neither transcript nor protein were detected by Northern and Western blot analyses of homozygous mutant brain tissues.
(J:82050)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Scn2b Mutation: |
14 strains or lines available
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| Original: |
J:82050 Chen C, et al., Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17072-7 |
| All: |
9 reference(s) |
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Analysis Tools
