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Cul3tm1Jro
Targeted Allele Detail
Summary
Symbol: Cul3tm1Jro
Name: cullin 3; targeted mutation 1, James M Roberts
MGI ID: MGI:2651546
Synonyms: Cul-3-, Cul3-
Gene: Cul3  Location: Chr1:80242640-80318197 bp, - strand  Genetic Position: Chr1, 41.24 cM, cytoband C4
Alliance: Cul3tm1Jro page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57761
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A PGK-neomycin resistance cassette replaced sequences that encode amino acids 127-293. Immunoblot analyses of fibroblasts from heterozygous mutant E16 embryos did not detect any truncated forms of the protein. (J:57761)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 14 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cul3 Mutation:  51 strains or lines available
References
Original:  J:57761 Singer JD, et al., Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 1999 Sep 15;13(18):2375-87
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory