Ptger2<tm1Sna> Targeted Allele Detail MGI Mouse (MGI:2651880)

Ptger2^tm1Sna
Targeted Allele Detail

Summary

Symbol:	Ptger2^tm1Sna
Name:	prostaglandin E receptor 2 (subtype EP2); targeted mutation 1, Shuh Narumiya
MGI ID:	MGI:2651880
Synonyms:	EP(2)-, EP2-, Ptger2-
Gene:	Ptger2 Location: Chr14:45225652-45241277 bp, + strand Genetic Position: Chr14, 22.68 cM
Alliance:	Ptger2^tm1Sna page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:70534
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The 3' portion of exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of uterine tissue obtained from homozygous mutant females. (J:57482, J:70534)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Tumor Data

List all tumor models in MMHCdb carrying Ptger2^tm1Sna

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ptger2 Mutation:	31 strains or lines available

References

Original:	J:70534 Ushikubi F, et al., Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature. 1998 Sep 17;395(6699):281-4
All:	50 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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