Sod3<tm1Mrkl> Targeted Allele Detail MGI Mouse (MGI:2652386)

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Sod3^tm1Mrkl
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Sod3^tm1Mrkl
Name:	superoxide dismutase 3, extracellular; targeted mutation 1, Stefan L Marklund
MGI ID:	MGI:2652386
Synonyms:	ecSOD^-, EC-SOD^-
Gene:	Sod3 Location: Chr5:52521146-52527080 bp, + strand Genetic Position: Chr5, 27.92 cM
Alliance:	Sod3^tm1Mrkl page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:26851
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: Sequence encoding the active site of the protein was disrupted by the insertion of a neomycin selection cassette. Superoxide dismutase activity was undetected in plasma obtained from homozygous mutant mice. (J:26851)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Sod3 Mutation:	13 strains or lines available

References

Original:	J:26851 Carlsson LM, et al., Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6264-8
All:	49 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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