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Cdontm1Rsk
Targeted Allele Detail
Summary
Symbol: Cdontm1Rsk
Name: cell adhesion molecule-related/down-regulated by oncogenes; targeted mutation 1, Robert S Krauss
MGI ID: MGI:2653120
Synonyms: Cdo-, CdonlacZ-1
Gene: Cdon  Location: Chr9:35332836-35418948 bp, + strand  Genetic Position: Chr9, 20.24 cM
Alliance: Cdontm1Rsk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82221
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The first coding exon was included in a 742 bp region deleted via homologous recombination. The targeting vector also contained an IRES-lacZ-neo cassette that replaced the 3' portion of exon 3. Endogenous protein was undetected by Western blot analysis of homozygous mutant mice. No beta-galactosidase activity was detected by staining. (J:82221)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 83 assay results
In Structures Affected by this Mutation: 17 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdon Mutation:  66 strains or lines available
References
Original:  J:82221 Cole F, et al., Microform Holoprosencephaly in Mice that Lack the Ig Superfamily Member Cdon. Curr Biol. 2003 Mar 4;13(5):411-5
All:  28 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory