Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol: Tg(Myh11-cre,-EGFP)2Mik Name: transgene insertion 2, Michael I Kotlikoff MGI ID: MGI:2653286 Synonyms: MH, smMHC-Cre, smMHC/Cre/eGFP, smMHCCre/eGFP, smMHC-Cre-GFPtg, smMHC-Cre-IRES-eGFP, Tg(Myh11-cre/EGFP)1Mik Transgene: Tg(Myh11-cre,-EGFP)2Mik  Location: unknown   Alliance: Tg(Myh11-cre,-EGFP)2Mik page

Shorter small intestines in mgi:5563563/mgi:5563563 mgi:2653286/0 and mgi:5563563/mgi:5563564 mgi:2653286/0 mice Show the 2 phenotype image(s) involving this allele.

Strain of Origin:

(C57BL/6 x DBA/2)F2

Transgene Type:    Transgenic (Recombinase, Reporter) Mutation:    Insertion   Tg(Myh11-cre,-EGFP)2Mik expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Myh11 (MGI:102643)   Mutation details: The transgene consists of a mouse Myh11 promoter, a cre recombinase gene, an internal ribosome entry site (IRES) and an enhanced GFP gene. 16 kb of mouse Myh11 promoter sequences was used to drive the bicistronic transgene expression in smooth muscle cells. The promoter has also been reported to be active in female germ cells. A low frequency of deletion events are also observed by inheritance from the male germline. (J:81358, J:138838)

Activity:	Tissue activity of this recombinase allele
Driver:	Myh11 (mouse) Summary of all recombinase alleles driven by Myh11. Comparative matrix view of recombinase activities Alliance mouse Myh11 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:81358 Xin HB, et al., Smooth muscle expression of Cre recombinase and eGFP in transgenic mice. Physiol Genomics. 2002 Sep 3;10(3):211-5
All:	79 reference(s)