Lepr<tm1Mgmj> Targeted Allele Detail MGI Mouse (MGI:2653294)

Lepr^tm1Mgmj
Targeted Allele Detail

Summary

Symbol:	Lepr^tm1Mgmj
Name:	leptin receptor; targeted mutation 1, Martin G Myers, Jr
MGI ID:	MGI:2653294
Synonyms:	lepr^s, lepr^S1138, s
Gene:	Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
Alliance:	Lepr^tm1Mgmj page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:82334
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Mutation
description

Allele Type:		Targeted
Mutation:		Nucleotide substitutions
		Mutation details: Tyrosine 1138 of exon 18b was replaced with a serine residue (Y1138S) and a neomycin resistance cassette was inserted into the downstream intron via homologous recombination. The Y1138S amino acid substitution specifically disrupts the leptin receptor long form (LRb)-STAT3 signal. Expression of the knock-in allele in mutant animals was confirmed by semi-quantitative RT-PCR analysis of hypothalamus RNA. (J:82334)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Lepr Mutation:	122 strains or lines available

References

Original:	J:82334 Bates SH, et al., STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature. 2003 Feb 20;421(6925):856-9
All:	20 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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