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Tnftm1Sek
Targeted Allele Detail
Summary
Symbol: Tnftm1Sek
Name: tumor necrosis factor; targeted mutation 1, Kenji Sekikawa
MGI ID: MGI:2653694
Synonyms: TNF-, TNF-alpha-, TNFalpha-, TNFalpha KO
Gene: Tnf  Location: Chr17:35418357-35420983 bp, - strand  Genetic Position: Chr17, 18.59 cM
Alliance: Tnftm1Sek page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44841
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: All of exon 3 and a portion of exon 4 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the DNA-binding domain (aa 84 through 174). (J:44841, J:92002)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:  48 strains or lines available
References
Original:  J:44841 Taniguchi T, et al., Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice. Lab Invest. 1997 Dec;77(6):647-58
All:  68 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory